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Alamethicin
| Product Name | Alamethicin |
| Product Code | A00003293 |
| Chemical name | Alamethicin |
| Synonyms | (3S,12R)-1-((S)-1-((6S,12S,15S,21S,30S)-1-((R)-1-(2-Acetamido-2-methylpropanoyl)pyrrolidin-2-yl)-15-(3-amino-3-oxopropyl)-30-isobutyl-21-isopropyl-3,3,6,9,9,2,18,18,24,24,33,33-dodecamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaoxo-2,5,8,11,14,17,20,23,26,29,32-undecaazatetratriacontan-34-oyl)pyrrolidin-2-yl)-12-(((R)-5-amino-1-(((S)-1-hydroxy-3-phenylpropan-2-yl)amino)-1,5-dioxopentan-2-yl)carbamoyl)-3-isopropyl-6,6,9,9-tetramethyl-1,4,7,10-tetraoxo-2,5,8,11-tetraazapentadecan-15-oic Acid; |
| Impurity | |
| CAS Number | 27061-78-5 |
| Alternate CAS # | NA |
| Molecular form | C₉₂H₁₅₀N₂₂O₂₅ |
| Appearance | Off-White to Brown Solid |
| Melting Point | >172°C (dec.) |
| Mol. Weight | 1964.31 |
| Storage | Refrigerator |
| Solubility | DMSO (Slightly ,Heated), Methanol (Slightly) |
| Stability | |
| Category | Aromatics, Peptides, Pharmaceuticals, Intermediates & Fine Chemicals |
| Boiling Point | |
| Applications | Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. Alamethicin contains the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib), which strongly induces helical peptide structures. In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules. |
| Dangerous Goods Info | NA |
| References | Afonin, S., et al.: Chembiochem., 4, 1151 (2003), Henriques, S., et al.: Biochem. J., 399, 1 (2006), Almeida, P., et al.: Biochemistry, 48, 8083 (2009), Heitz, F., et al.: Br. J. Pharmacol., 157, 195 (2009), |
| Extra Notes | |
| Documents (MSDS) | No Data Available |
| Keywords | Buy 27061-78-5 | Purchase 27061-78-5 | Order 27061-78-5 | 27061-78-5 supplier | 27061-78-5 manufacturer | 27061-78-5 distributor | 27061-78-5 cost |
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