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Acetaminophen-cysteine
| Product Name | Acetaminophen-cysteine |
| Product Code | A0000620 |
| Chemical name | Acetaminophen-cysteine |
| Synonyms | S-[4-(Acetylamino)phenyl]-L-cysteine; |
| Impurity | |
| CAS Number | 64014-06-8 |
| Alternate CAS # | NA |
| Molecular form | C₁₁H₁₄N₂O₃S |
| Appearance | Off-White Solid |
| Melting Point | >184°C (dec.) |
| Mol. Weight | 254.31 |
| Storage | Refrigerator |
| Solubility | Aqueous Acidic (Slightly) |
| Stability | |
| Category | |
| Boiling Point | |
| Applications | Acetaminophen-cysteine is a metabolite of Acetaminophen (A161220) and a serum biomarker of acetaminophen exposure (1,2). Acetaminophen-cysteine can be used to identify acetaminophen-induced acute liver failure when standard testing is inconclusive. Acetaminophen is oxidized by cytochrome P450 to a reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which can react with cysteine residues of hepatic proteins to yield Acetaminophen-cysteine (3). |
| Dangerous Goods Info | NA |
| References | (1) Frey, S. M., et al.: J Med Toxicol. 11, 218 (2015) (2) O’Malley G. F., et al.: J Med Toxicol. 11, 317 (2015) (3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013) |
| Extra Notes | |
| Documents (MSDS) | Download Document |
| Keywords |
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