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(E)-3-(4-Amino-3,5-bis(methoxymethyl)phenyl)acrylonitrile
| Product Name | (E)-3-(4-Amino-3,5-bis(methoxymethyl)phenyl)acrylonitrile |
| Product Code | E00007029 |
| Chemical name | (E)-3-(4-Amino-3,5-bis(methoxymethyl)phenyl)acrylonitrile |
| Synonyms | |
| Impurity | |
| CAS Number | |
| Alternate CAS # | |
| Molecular form | C₁₃H₁₆N₂O₂ |
| Appearance | Light Yellow Solid |
| Melting Point | |
| Mol. Weight | 232.28 |
| Storage | |
| Solubility | Dichloromethane, Ethyl Acetate, Methanol |
| Stability | |
| Category | |
| Boiling Point | |
| Applications | (E)-3-(4-Amino-3,5-bis(methoxymethyl)phenyl)acrylonitrile is an intermediate in the synthesis of 2,6-Dihydroxymethyl Rilpivirine (D446615), which is an analog of Rilpivirine (R509800) a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent. |
| Dangerous Goods Info | |
| References | Sun, et al.: J. Med. Chem., 41, 4648 (1998), Kashiwada, et al.: Bioorg. Med. Chem. Lett., 11, 183 (2001); Griffin, D. et al.: J. Am. Chem. Soc., 134, 13103 (2012); |
| Extra Notes | |
| Documents (MSDS) | No Data Available |
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