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AG-490
| Product Name | AG-490 |
| Product Code | A00003112 |
| Chemical name | AG-490 |
| Synonyms | 2-Cyano-3-(3,4-dihydroxyphenyl)-N-(phenylmethyl)-2-propenamide; Tyrphostin B 42; |
| Impurity | |
| CAS Number | 134036-52-5 |
| Alternate CAS # | NA |
| Molecular form | C₁₇H₁₄N₂O₃ |
| Appearance | Dark Yellow Solid |
| Melting Point | >213°C (dec.) |
| Mol. Weight | 294.3 |
| Storage | -20°C Freezer |
| Solubility | Acetone, Chloroform, DMSO, Ethanol, Methanol |
| Stability | |
| Category | Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors, |
| Boiling Point | |
| Applications | A potent and specific inhibitor of the Jak-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. AG-490 is cell permeable and is active in vivo. |
| Dangerous Goods Info | Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g in the package |
| References | Stock, J., et al.: J. Biol. Chem., 267, 19753 (1992), Levitzki, A., et al.: Science, 267, 1782 (1995), Meydan., N., et al.: Nature, 379, 645 (1996), Lu, H., et al.: Drug Metab. Dispos., 31, 572 (2003), |
| Extra Notes | |
| Documents (MSDS) | Download Document |
| Keywords | Buy 134036-52-5 | Purchase 134036-52-5 | Order 134036-52-5 | 134036-52-5 supplier | 134036-52-5 manufacturer | 134036-52-5 distributor | 134036-52-5 cost |
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