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Abacavir-d4

Product Name Abacavir-d4
Product Code A000070
Chemical name Abacavir-d4
Synonyms (1S,4R)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene-1-methanol;(1S-cis)-4-[2-Amino-6-(cyclopropylamino-d4)-9H-purin-9-yl]-2-cyclopentene- 1-methanol; 1592U89-d4; ABC-d4; Abacavir Stable Isotope
Impurity
CAS Number 1217731-56-0
Alternate CAS # 136470-78-5-unlabelled
Molecular form C₁₄H₁₄D₄N₆O
Appearance Off-White to Light Beige Solid
Melting Point >70°C (dec.)
Mol. Weight 290.36
Storage Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Solubility DMSO (Slightly), Methanol (Slightly)
Stability Very Hygroscopic
Category Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals,
Boiling Point
Applications Abacavir-d4 is deuterium labeled Abacavir (A104990). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info NA
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
Extra Notes
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Abacavir-d4
Product Packings
1mg
10mg
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