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Abacavir

Product Name Abacavir
Product Code A000066
Chemical name Abacavir
Synonyms (1S,4R)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1S-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; 1592U89; ABC; Abacavir API; Abacavir Impurities
Impurity Abacavir API
CAS Number 136470-78-5
Alternate CAS # NA
Molecular form C₁₄H₁₈N₆O
Appearance Off-White Solid
Melting Point 94-97°C
Mol. Weight 286.33
Storage Refrigerator
Solubility DMSO (Slightly, Heated), Methanol (Slightly)
Stability
Category Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point
Applications Abacavir (Abacavir API) is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info NA
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
Extra Notes
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Abacavir
Product Packings
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50mg
100mg
250mg
500mg
1g
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