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ent-Abacavir

Product Name ent-Abacavir
Product Code E000072
Chemical name ent-Abacavir
Synonyms (1R,4S)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R-cis)-4-[2-Amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol; (1R,4S)-Abacavir; Abacavir EP Impurity A; Abacavir Impurities; Ent-Abacavir
Impurity Abacavir EP Impurity A
CAS Number 136470-79-6
Alternate CAS # NA
Molecular form C₁₄H₁₈N₆O
Appearance Off-White to Pale Yellow Solid
Melting Point >77°C (dec.)
Mol. Weight 286.33
Storage Refrigerator
Solubility DMSO (Slightly), Methanol (Slightly)
Stability
Category Anti-virals, Inhibitors, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
Boiling Point
Applications ent-Abacavir (Abacavir EP Impurity A) is an enatiomer of Abacavir (A105000). Abacavir is a carbocyclic 2’-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
Dangerous Goods Info NA
References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
Extra Notes
Documents (MSDS) No Data Available
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ent-Abacavir
Product Packings
1mg
2.5mg
25mg
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